Description
 Product Overview
QuantaNova’s Epithalon (also known as Epitalon) is a synthetic tetrapeptide, formulated in a 10mg lyophilized powder and bundled in a 4-pack. Each vial is manufactured using in-house lyophilization techniques and stabilized with a proprietary formula to preserve its integrity during temperature shifts for up to 30 days. This ensures optimal peptide potency in transit. PES micron filtration is used before the final freeze drying process to eliminate the potential for bacterial contamination. All new batches are independently tested by Vanguard Laboratory for identity, purity, endotoxins, and quantity, ensuring consistency in every lot.
 Epithalon Peptide Structure
- Amino Acid Sequence: Ala-Glu-Asp-Gly
- Molecular Formula: C14H22N4O9
- Molecular Weight: 390.35 g/mol
- CAS Number: 307297-39-8
Key Findings of Epithalon
- Epithalon & Aging – May influence telomerase activity, a key enzyme involved in cellular longevity.
-  Skin Vitality – Linked to enhanced skin thickness, elasticity, and reduced appearance of aging.
- Epithalon & Regulation of Sleep Patterns – Associated with improved melatonin secretion and circadian balance.
- Explored for Tumor Modulation – Examined for its role in regulating abnormal cell growth in controlled models.
- Epithalon & Vision – Connected to improved retinal structure and eye function in age-related models.
In-Depth Research Applications of Epithalon
Epithalon and Telomerase Activation
Epithalon is most recognized for its influence on telomerase, an enzyme that maintains and extends telomeres—protective caps on the ends of chromosomes. Shortened telomeres are a hallmark of cellular aging, and Epithalon has been studied for its potential to delay cellular senescence by enhancing telomerase activity. In vitro and animal models have shown that Epithalon can increase the expression of telomerase in somatic cells, potentially extending their replicative lifespan.
Beyond cellular longevity, these effects are hypothesized to preserve chromosomal stability and delay the accumulation of DNA damage, especially in tissues with high turnover rates. The peptide’s telomerase-related mechanisms have been a focal point for research into aging interventions, regenerative science, and age-associated tissue degeneration.
Epithalon and Melatonin Secretion
Epithalon has been shown to modulate melatonin secretion by acting on the pineal gland. Aging is often accompanied by a decline in melatonin production, which disrupts circadian rhythms and impacts sleep quality. Research indicates that Epithalon may help restore rhythmic melatonin levels in aging subjects, thereby supporting sleep-wake cycles and neuroendocrine synchronization.
Additional studies suggest that normalized melatonin output, achieved through Epithalon administration, may support mitochondrial function and immune modulation. The peptide’s interaction with pineal regulation has opened research avenues exploring its role in metabolic health, seasonal affective regulation, and endocrine signaling pathways involved in aging.
Epithalon and Tumor Growth Regulation
Scientific literature has investigated Epithalon’s potential involvement in controlling abnormal cell proliferation. In multiple rodent models, Epithalon administration correlated with decreased incidence of spontaneous tumor formation and modulation of apoptosis-related pathways. These findings suggest that Epithalon may interact with gene expression profiles related to oncogenesis.
Moreover, Epithalon appears to exert selective effects on transformed versus normal cells, indicating possible homeostatic balancing of cell division in aging tissues. While further mechanistic clarification is needed, early-stage studies support continued investigation into Epithalon as a potential research tool for oncological and cell regulatory research.
Epithalon and Skin Health
Studies have shown that Epithalon may influence fibroblast activity, enhance collagen synthesis, and reduce oxidative damage in skin tissue. In aging models, these effects translate to improved skin elasticity and reduced visible markers of dermal aging. By promoting protein cross-link repair and stabilizing extracellular matrix components, Epithalon has been explored as a potential anti-aging agent in dermatological research.
Additionally, its potential to reduce reactive oxygen species (ROS) in dermal layers makes it an attractive candidate for studying oxidative stress modulation. Research continues into how this tetrapeptide may protect against UV-induced degradation and environmental damage to skin cells.
Epithalon and Vision Support
Epithalon has also been studied for its impact on visual system health, particularly in models of age-related retinal degeneration. Research suggests the peptide may influence neuroretinal signaling pathways and support the preservation of retinal sensitivity. Improvements in visual signal clarity and retinal cell survival have been observed in some preclinical studies.
These effects may be linked to Epithalon’s broader role in neuroendocrine regulation and mitochondrial efficiency. As vision-related degeneration becomes more prevalent with age, the potential for peptides like Epithalon to mitigate age-associated decline has become a topic of growing interest in ophthalmologic research.
Resources
- Epithalon and Telomerase Activation
- Epithalon and Melatonin Secretion
- Epithalon and Tumor Growth Regulation
Usage & Storage Guidelines of Epithalon
- Handle using appropriate laboratory safety procedures.
- Storage (Lyophilized): Store at -20°C.
- After Reconstitution: Store between 2–8°C and use within 14–30 days.
- Diluent Recommendation: Reconstitute with bacteriostatic water or a suitable research-grade diluent.
Legal Disclaimer
This product is intended strictly for laboratory research purposes only. It is not a drug, food additive, cosmetic, or therapeutic substance, and must not be used in humans or animals. It is the buyer’s responsibility to handle the product safely and in accordance with applicable laws and regulations.
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